Natural Vitamin E
Crude Palm Oil is the richest natural source of Tocotrienols. The Malaysian Palm Oil Board (MPOB) has developed a special patented technology for extraction. The latest technology to purify Tocotrienols from the fruits of oil palm (Elais guineensis) was developed to produce a superior quality and purity.
What are Tocotrienols?
Tocotrienols are members of the Vitamin E family comprising of Tocotrienols and Tocopherols. Tocotrienols differ from the Tocopherol's in that they contain three double bonds in the side-shain (see molecular structure). Tocotrienols Isoprenoid side chain has three double bonds as compared to Tocopherol's saturated side-chain. In total, there are four types Tocopherols namely alpha, beta, gamma and delta and four corresponding of Tocotrienols isomers.
Vitamin E is essential for maintaining heart and blood health within the body. A diet rich in lycopene can help ward off heart disease and certain cancers.
Cooking palm fruit oil remains the largest source of tocotrienols – a form of vitamin E known to man. This helps in protecting the body against diseases like cancer, blood disorders, and help maintains good skin and fertility.
Palmvitee (palm tocotrienol capsules manufactured by PORIM) showed a cholesterol reducing effect in hypercholesterolemic humans.
Qureshi A. et al. (1991), “Dietary tocotrienols reduce concentrations of plasma cholesterol, apolipoprotein B, thromboxane B2 and platelet factor 4 in pigs with inherited hyperlipidemias.” Am. J Clin Nutr., 53: 1042S - 1046S
The use of tocotrienols, tocotrienol-like compound and mixture as hypercholesterolemic, antithrombotic, antioxidizing, anti-inflammatory and immunoregulatory agents or as agents useful to decrease lipoprotein-alpha concentration or to increase food conversion efficiency.
Qureshi A. et al. (1994), “United States Patent Number: 5,348,974: Tocotrienols in the treatment of hypercholesterolemia, hyperlipidemia and thromboembolic disorders”. Assignee: Bristol-Myers Squibb Co. New York. (b)Qureshi A. et al. (1997), “Tocotrienols and tocotrienols-like compounds and methods for their use.” Assignee : Lipogenics, Inc, Scottsdale, Arizona.
Tocotrienols have been shown to suppress cholesterol biosynthesis and reduce cholesterol level in chicken.
Qureshi A. et al. (1988), National Oil Palm/Palm Oil Conference : Current Development 11 -12th October 1988. Kuala Lumpur.
Dr Watkins of Fairleigh Dinkinson University, New Jersey showed that a combination of gamma-tocotrienol and alpha-tocopherol as found in palm oil vitamin E deserved further evaluation as a potential hypolipemic agent in hyperlipemic humans with atherogenic risk.
Watkins, T. et al. (1993), “Gamma-Tocotrienol as Hypocholesterolemic and Antioxidant Agent in Rats Fed Atherogenic Diets”. Lipids, 28 (12) : 1113-1118.
Palm tocotrienols inhibited cholesterogenesis by suppressing HMG-CoA reductase through a novel post-transcriptional mechanism.
Parker, R.A. et al.(1990), “Tocotrienols Decrease Cholesterol Synthesis in HEPG2 Cells by A Novel Post-Transcriptional Suppression of HMG-CoA Reductase”. FASEB J., 4:1744A.
Intake of tocotrienols or lovastatin plus AHA Step 1 diet significantly lower serum total cholesterol and LDL-cholesterol in hypercholesterolemic humans
Qureshi A. et al. (2001). “Synergistic Effect of Tocotrienol-rich Fraction (TRF 25) of Rice Bran and Lovastatin on Lipid Parameters in Hypercholesterolemic Humans.” J. Nutr. Biochem. 12: 318-29.
Prof. Khor from University of Malaya at Kuala Lumpur showed that palm tocotrienols exhibited inhibitory effect on liver HMG CoA reductase activity and alpha tocopherol attenuated the inhibitory effect of palm tocotrienols on liver HMG CoA reductase
Khor HT. et al. (2000). “Effects of Administration of alpha-Tocopherol and Tocotrienols on Serum Lipids and Liver HMG Co-A Reductase Activity. Int’l. J. Food Sci. Nutr. 51: S3-S11.
Prof. Nafeeza from the National University of Malaysia demonstrated that palm tocotrienols improve important lipid parameters and reduced lipid peroxidation in rabbits despite intake of highly atherogenic diet
Nafeeza MI. et al. (2000). “Vitamin E and Factors Affecting Atherosclerosis in Rabbit Fed with A Cholesterol-Rich Diet.” Intl. J. Food Sci. Nutr. 51: S79-S94.
Palm tocotrienols and alpha-tocopherol enhanced the serum cholesterol-lowering effect of dietary squelene in the liver of hamsters
Khor HT. et al. (1997). “Effect of Squalene, Tocotrienols, and alpha-Tocopherol Supplementations in The Diet on Serum and Liver Lipids in The Hamster.” Nutr. Res. 17(3): 475-83
Tocotrienols reduce total cholesterol, LDL-cholesterol, Apo B, platelet factor 4 and thromboxane B2 in hypercholesterolemic human subjects
Qureshi A. et al. (1997). “Novel Tocotrienols of Rice Bran Modulate Cardiovascular Disease Risk Parameters of Hypercholesterolemic Humans. J. Nutr Biochem 8:290-8.
Palm tocotrienols reduce cholesterol in hypercholesterolemic humans and alpha-tocopherol attenuates the cholesterol-suppressive action of the tocotrienols
Qureshi A. et al. (1995). “Response of Hypercholesterolemic Subjects to Administration of Tocotrienols.” Lipids. 30: 1171-77.
Palm tocotrienols inhibit liver HMG CoA Reductase activity in guinea pig.
Khor HT. et al. (1995). “Tocotrienols Inhibit Liver HMG CoA Reductase Activity in the Guinea Pig.” Nutr. Res. 15(4): 537-44.
Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-Hydroxy-3-Methylglutaryl CoA Reductase.
Parker RA. et al. (1993). “Tocotrienols Regulate Cholesterol Production in Mammalian Cells by Post-Transcriptional Suppression of 3-Hydroxy-3-Methylglutaryl CoA Reductase.” J. Biol. Chem. 26(15): 11230-8.
Tocotrienols decrease plasma cholesterol, low and very low density lipoprotein cholesterol and triglyceride in rats fed atherogenic diets
Watkins T. et al. 91993). “gamma-Tocotrienols as A Hypocholesterolemic and Antioxidant Agent in Rats fed Atherogenic Diets.” Lipids. 28: 1113-8.
Gamma tocotrienol exhibits a 30-fold greater activity toward cholesterol biosynthesis inhibition compared to alpha tocotrienol in HepG2 cells in vitro
Pearce BC. et al. (1992). “Hypocholesterolemic Activity of Synthetic and Natural Tocotrienols.” J. Med. Chem. 35(20): 3595-606.
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