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Palm Oil Benefits

Scientific studies conducted at the Universities of Louisiana and Wisconsin in the USA, the University of Reading in the UK, and the University of Western Ontario in Canada, have identified the following nutrition benefits of red palm oil:

  • Reduction in the incidence of arteriosclerosis (hardening of the arteries which can result in heart disease);
  • Reduction in blood cholesterol levels;
  • Reduction in blood clotting, combined with blood vessel dilation, thus preventing heart attacks and strokes;
  • Inhibition of the growth of breast cancer cells, which suggests that red palm oil may act as a chemo preventive agent;
  • 45% enhancement of the efficiency of breast cancer drugs such as Tamoxifen.

Nagendran b. et al., (2000), “Characteristics of red palm oil, a carotene- and vitamin E-rich refined oil for food uses”, Food and Nutrition Bulletin, Vol 21(2):189-194

The bio-availability of beta-carotenes from red palm oil and synthetic beta-carotene is similar. However, red palm oil is a better choice as it contains bouquets of carotenoids rather than just a single type of carotene.

Van Het Hof K.H. et al. (1999), “Comparison of the bioavailability of natural palm oil carotenoids and synthetic beta-carotene in humans”, J Agric Fd Chem 47(4): 1582-1586

Atherosclerosis (ath-er-o-skler-O-sis) is a disease in which plaque (plak) builds up on the insides of your arteries.

Dr. David Kritchevsky of the Wistar Institute in Philadelphia, US demonstrated that CAROTINO red palm oil is the least atherogenic oil compared to refined, bleached, deodorized palm oil and randomized palm oil. The anti-atherogenic attributes of red palm oil is due to the presence of abundant amounts of antioxidants, particularly the carotenoids and tocotrienols.

Kritchevsky D, et al., (2001), “Red palm oil in experimental atherosclerosis”, Proceedings of Food Technology & Nutrition Conference, International Palm Oil Congress 2001, Kuala Lumpur, Malaysia

CAROTINO red palm oil decreased significantly tissue plasminogen activator antigen, an important independent risk factor for coronary heart disease, compared to palm oil and sunflower oil.

Scholtz et al. (2004), “The effect of red palm olein and refined palm olein on lipids and haemostatic factors in hyperfibrinogenaemic subjects”. Thrombosis research 113:13-25

CAROTINO red palm oil improves reperfusion cardiac function in the isolated perfused rat heart of animals through mechanisms that may include activation of the NO-cGMP and inhibition of the camp pathway.

Esterhuyse et al. (2004), “Dietary red palm oil improves reperfusion cardiac function in the isolated perfused rat heart of animals fed a high cholesterol diet”. Prostaglandins, Leukotrienes and EFA 72: 153-161

Heating of Red Palm Oil
Long term heating of CAROTINO red palm oil does not have adverse effect on serum triglyceride, HDL and TC/HDL ratios.

Kamsiah J., et al. (2001), “Changes in serum lipid profile and malondialdehyde following consumption of fresh or heated red palm oil”, Proceedings of Food Technology & Nutrition Conference, International Palm Oil Congress 2001, Kuala Lumpur, Malaysia

Cancer Prevention

Palm oil carotene concentrate may prevent the development of hormone-dependent breast cancers

Lai Leslie, et al., “ Effect of retinoic acid and palm oil concentrate on oestrone sulphatase and oestradiol-17beta hydroxysteroid dehydrogenase activities in MCF-7 and MDA-MB-231 breast cancer cell lines”, International Journal of Cancer, Vol.88; pp : 135-138, 2000.

Palm oil carotene concentrate caused dose-dependent inhibition of estradiol stimulated growth of MCF-7, estrogen receptor positive human breast cells

Nesaretnam K, et al., “Effect of a carotene concentrate on the growth of human breast cancer cells and pS2 gene expression”, Toxicology, Vol. 151(1-3); pp : 117-126, 2000.

A group of Japanese scientists showed that various natural carotenoids have anticarcinogenic activity. Alpha-carotene showed higher potency than beta-carotene to suppress experimental carcinogenesis. Based on these results, multi-carotenoids (mixture of natural carotenoids) seems to be of interest to evaluate usefulness for practise in human cancer prevention

Nishino H, et al., “Cancer prevention by natural carotenoids”, Biofactors, Vol. 13(1-4) : pp : 89-94, 2000.

Vitamin A, alpha-carotene and lycopene were associated with strong inverse relationships with stomach cancer

De Stefani, et al., “Dietary carotenoids and risk of gastric cancer: A case-control study in Uruguay”, Eur. J. Cancer Prevention, Vol.(5); pp : 329-334, 2000.

Alpha carotene and lycopene intakes were significantly associated with a lower risk of lung cancer. The association with beta-carotene, lutein and beta-cryptoxanthin intakes were inverse but not significant

Giovannucci E, et al., “Intake of specific carotenoids and risk of lung cancer in 2 prospective US cohorts”, Am . J. Clin .Nutr., Vol. 7294); pp : 990-997,2002.

Combined administration of palm carotene and green tea polyphenols might be a candidate for chemoprevention strategy for pancreatic cancer in humans

Konishi Y, et al., “Inhibitory effects of beta-carotene, palm carotene and green tea Polyphenols on pancreatic carcinogenesis initiated by N-nitorsobis(2-oxopropyl) amine in Syrian golden hamsters”, Pancreas, Vol. 16(1); pp : 13-18, 1998.

When the cases were separated into oesophageal, laryngeal and oral-pharyngeal cancer, both alpha-carotene and beta carotene were consistently and strongly associated with reduced risk at each site

Craft NE, et al, “Serum micronutrients and upper aero digestive cancer”, Cancer Epidemiol. Biomakers Prev., Vol. 6(6); pp : 407-412, 1997.

Alpha-carotene showed higher potency than beta-carotene in suppressing experimental carcinogenesis. Further studies on various natural carotenoids besides beta-carotenes should be continued to obtain more information about potential of natural carotenoids in the field of cancer prevention

Nishino H, “Cancer prevention by natural carotenoids’, J. Cell Biochem Suppl., Vol 27; pp : 86-89, 1997.

The Japanese researchers showed that alpha-carotene but not beta-carotene reduced the number of lung tumours per mouse compared to control group. This higher potency of the anti-tumour promoting action of alpha-carotene compared to beta-carotene was confirmed in other experimental systems. These studies suggest that not only beta carotene but also other types of carotenoids such as alpha-carotene may plan an important role in cancer prevention

Murakoshi, M, et al. “Potent preventive action of alpha-carotene against carcinogenesis: Spontaneous liver carcinogenesis and promoting stage of lung and skin carcinogenesis in mice are suppressed more effectively by alpha-carotene than beta-carotene; Cancer Research , Vol. 52; pp : 6583-6587, 1992.

Natural carotene sample obtained from palm oil was proved to suppress the promoting stage of two-stage carcinogenesis of mouse skin and also inhibit the proliferation of human malignant tumor cells such as neuroblastoma GOTO cells, stomach cancer HGC-27 cell and pancreatic cancer PANC-I cells. Among the major constituents of palm carotene, alpha-carotene showed stronger anti-proliferative effect than beta-carotene. Results indicate that further investigation for not only beta-carotene but also other kinds of natural carotenes such as alpha-carotene should be carried out

Imanishi J, et al., “Anticarcinogenesis activity of natural carotenes”, C.R.Seances Soc. Biol. Fil., Vol. 183(1); pp : 85-89, 1989.

Among the various individual carotenoids considered, inverse associations were observed for alpha-carotene, beta carotene and lutein/zeaxanthin for colectal cancer

La Vecchia C, et al., “Selected micronutrients and colectal cancer : A case control study from Canton of Vaud, Switzerland”, Eur. J. of Cancer, Vol.36(16); pp : 2115-2119, 2000.

The dietary intake of several carotenoids in 332 lung cancer patients was compared to that of 865 cancer free controls. After adjusting for smoking and other risk factors, researchers reported that the lowest risk of lung cancer occurred in those with the highest intake of beta-carotene, alpha- carotene, and lutein.

Le Marchand L. et al, "Intake of specific carotenoids and lung cancer risk," Cancer Epidemiology, May/June1993;2:183-187.

Alpha-carotene inhibited the growth of human cancer cells grown in the laboratory, and the higher the dose of alpha-carotene, the stronger the inhibitory effect.

Murakoshi M., et al, "Inhibitory effects of alpha-carotene an proliferation of the human neuroblastoma cell line GOTO," Journal of the national Cancer Institute, 1989;81:1649-1652.

Alpha-carotene drastically reduced the number of tumours in an animal study of liver, lung and skin cancer. The cancer fighting ability of alpha-carotene exceeded that of beta-carotene.

Murakoshi M et al,"Potent preventive action of alpha-carotene against carcinogenesis: Spontaneous liver carcinogenesis and promoting stage of lung and skin carcinogenesis in mice are suppressed more effectively by alpha-carotene than by beta-carotene," Cancer Research. December1992;52 :6583-6587.

Both alpha-and beta-carotene have chemopreventive effects on croton oil-induced tumour promotion in skin tumorigenesis

Kim-Jun H, “Inhibitory effects of alpha-and beta-carotene on croton oil-induced or enzymatic lipid peroxidation and hydroperoxide production in mouse skin epidermis”, Int. J. Biochem, Vol 25(6); pp : 911-915, 1993.

Palm fruit carotene had no mutagenic activity in vitro and in vivo tests

Nakamura T, et al., “Mutagenicity studies with palm fruit carotene”, J. Toxicol Sci., Vol. 20(5); pp : 619-627, 1995.

Higher serum level of alpha-carotene was significantly associated with decreased risk of cervical dysplasia. Decreased risk observed for the highest tertiles of beta- carotene and zeaxanthin/lutein were not statistically significant

Kawana T, el al., “Serum carotenoids and vitamins and risk of cervical dysplasia from a case control study in Japan”, Br. J . Cancer, Vol. *1(7); pp : 1234-1237, 1999.

The intake of carotenes, especially alpha-carotene, from food and supplements significantly reduce risk of ovarian cancer, predominantly in postmenopausal women

Cramer DW et al., “Carotenoids, antioxidants and ovarian cancer in pre- and postmenopausal women”, Int J Cancer, 1;94(1)128-34, 2001.

Risk of breast cancer increases with decreasing serum concentration of beta-carotene, lutein, alpha-carotene and beta-cryptoxanthin

Toniolo et al., “Serum carotenoids and breast cancer”, Am J Epidemiol., 15;153(12):1142-7, 2001

Indian women with breast cancer or of other sides might have low intake of carotenoids such as beta-carotene, zeaxanthin and lutein

Ito Y et al., “A study on serum carotenoid levels in breast cancer patients of Indian women in Chenai, India”, India J Epidermio., 9(5):306-14, 1999

This study results show that carotenoids may protect against the development of breast cancer

Sato R et al., “Prospective study of carotenoids, tocopherols and retenoid concentrations and the risk of breast cancer”, Cancer Epidemiol Biomarkers Prev., 11(5):451-7, 2002

Plasma levels of beta-carotene and alpha-tocopherol were inversely correlated with gastric cancer rates in Japan

Tsubono y et al., “Plasma antioxidant vitamins and carotenoids in five Japanese populations with varied mortality from gastric cancer”, Nutr Cancer, 34(1):56-61, 1999

Kyoto Prefectural University of Medicine showed that carotenoids from palm fruit oil are potent chemo preventive agents.

Murakoshi et al. Papers submitted by Kyoto Prefectural University of Medicine, Japan

Alpha-carotene is the most powerful chemo preventive agent against liver and lung tumour compared to beta-carotene and alpha-tocopherol.

Tsuda et al. (1994), “Chemo preventive potential of alpha-carotene against mouse liver and lung tumour development: comparison with beta-carotene and alpha tocopherol”. Japanese J. Cancer Res. 85: 1214-1219.

Lycopene, lutein, alpha-carotene and palm carotenes may potentially prevent colon cancer.

Narisawa et al. (1996), “Inhibitory effects of natural carotenoids, alpha carotene, beta carotene, lycopene and lutein, on colonic aberrant crypt foci formation in rat”. Cancer letters 107: 137-142

Dietary supplementation of red palm oil may have the potential to prevent oestradiol induced breast cancer carcinogenesis at the initiation.

Yu et al. (2005), “Studies on the preventive effect of red palm oil and the potential against breast cancer carcinogenesis at the initiation”. Proceedings of PIPOC 2005:192-201

Cholesterol Lowering Effects

Dr. Qureshi at University of Wisconsin showed that alpha-tocotrienol has been shown to inhibit the biosynthesis of cholesterol.

Qureshi A. et al. (1986), “The structure of an inhibitor of cholesterol biosynthesis isolated from barley.” J.Biol.Chem. 251: 554-555.

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